Manganese is a trace element that is necessary in small amounts for a variety of biological functions. It supports the activity of several enzymes important for energy metabolism, bone health, wound healing, and protection against oxidative stress. Manganese is also involved in the formation of connective tissue and the regulation of blood sugar.

A deficiency is rare but can lead to growth disorders, impairments in fat and carbohydrate metabolism, as well as neurological symptoms.

An excess is also possible and can have toxic effects, particularly on the nervous system.