What is C-reactive protein (CRP)?
C-reactive protein (CRP) is a protein molecule that is produced in the liver and enters the bloodstream during inflammatory processes . As a so-called "acute phase protein", the CRP value rises rapidly when tissue damage or infections occur.
CRP supports the immune system by activating pro-inflammatory molecules and making it easier to fight pathogens. Since the CRP level rises just a few hours after the onset of inflammation , it is a particularly sensitive and reliable marker for acute inflammatory reactions in the body.
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reference range of the CRP value
Which values are normal?
Under normal conditions, the CRP level in the blood is very low and is often barely detectable. In general, a CRP level of less than 5 mg/L is considered normal.
For a more precise assessment, a distinction is often made between slightly elevated (5–10 mg/L), moderately elevated (10–40 mg/L) and strongly elevated values (over 40 mg/L).
Tabular overview
Below 5 mg/L: Normal range
5–10 mg/L: Mild inflammation possible
Over 10 mg/L: Possible acute inflammation or infection
Causes of elevated CRP levels
An elevated CRP value is not specific to a single disease, but indicates an inflammatory reaction in the body. The possible causes are varied:
- Acute infections: Bacterial infections often lead to greatly increased CRP levels. In viral infections, the level also increases, but usually less significantly.
- Chronic inflammation: Diseases such as rheumatism, arthritis or chronic inflammatory bowel diseases (e.g. Crohn's disease or ulcerative colitis ) can cause permanently elevated CRP levels.
- Injuries and surgeries: After injuries or surgical procedures, the CRP level increases as the body activates healing and responds to possible infections.
- Autoimmune diseases: In diseases such as lupus or multiple sclerosis , in which the immune system attacks the body's own cells, increased CRP levels can also be detected.
- Cardiovascular diseases: Slightly elevated CRP levels (approx. 1–3 mg/L ) may indicate an increased risk of cardiovascular diseases such as heart attack or stroke .
CRP: A versatile marker in diagnostics
The CRP value is often used in combination with other tests to obtain a more comprehensive picture of the state of health. An elevated CRP value alone is rarely sufficient for a diagnosis, but serves as a supplementary marker to localize inflammation in the body or to monitor its progression. In the case of chronic diseases or autoimmune diseases in particular, the CRP value helps to monitor the course of the disease and to assess the effectiveness of therapies .
CRP and cardiac risk
In cardiology, the so-called hsCRP test (highly sensitive CRP test) is used. This measures particularly low CRP values in the range of 0.1 to 3 mg/L and can detect even minor inflammation. An increased hsCRP value can indicate an increased risk of cardiovascular disease , even if no typical symptoms are present. The hsCRP test is therefore an important tool for identifying people who are symptom-free but are still at risk of arteriosclerosis or a heart attack .
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What now? Next steps for your health
The CRP value is an extremely useful parameter for detecting inflammation at an early stage and monitoring its progression. Whether for diagnosing acute infections , controlling chronic inflammation or as a risk marker for cardiovascular diseases – the CRP value has many uses.
Regular checks of the CRP value make it possible to identify health problems more quickly and treat them specifically.
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FAQ: Frequently asked questions about stress, burnout and cortisol levels
What is the CRP value and why is it important?
What is the CRP value and why is it important?
The CRP (C-reactive protein) level is a marker for inflammation in the body. It indicates whether there is acute or chronic inflammation and is often used to assess the severity and cause of inflammation.
How is the CRP value measured?
How is the CRP value measured?
The CRP level is determined by a blood test. A simple blood sample is enough to measure the CRP level and detect possible inflammatory processes in the body.
What reference ranges are there for the CRP value?
What reference ranges are there for the CRP value?
A normal CRP level is below 5 mg/L. Levels between 5 and 10 mg/L indicate mild inflammation, while levels above 10 mg/L may indicate acute inflammation or infection. A high CRP level is often a sign of severe inflammation.
What can elevated CRP levels mean?
What can elevated CRP levels mean?
An increased CRP level indicates an inflammatory reaction in the body. Possible causes include bacterial infections, autoimmune diseases, injuries or chronic inflammation such as arthritis. Cardiovascular diseases can also be associated with slightly increased CRP levels.
What symptoms can indicate a high CRP level?
What symptoms can indicate a high CRP level?
Since the CRP level is only a marker for inflammation, it does not indicate any specific symptoms by itself. However, symptoms of inflammation can include fever, pain, swelling, fatigue and redness. A CRP test is often performed to clarify the cause of these symptoms.
What is the difference between CRP and hs-CRP?
What is the difference between CRP and hs-CRP?
The hs-CRP (high-sensitivity CRP) measures very low levels of CRP and is often used to assess cardiovascular risk. While the regular CRP test measures acute inflammation, the hs-CRP test shows subtle inflammation that may be associated with a higher risk of heart disease.
What can I do to lower my CRP level?
What can I do to lower my CRP level?
A healthy lifestyle can help lower CRP levels. Regular exercise, an anti-inflammatory diet, adequate sleep and stress management help reduce inflammation. Acute inflammation may require treatment with medication.
When should the CRP level be checked?
When should the CRP level be checked?
The CRP level should be checked if acute or chronic inflammation is suspected or if symptoms such as fever, joint pain or fatigue occur. The hs-CRP level can also be helpful in assessing the risk of cardiovascular disease.
Can medications affect CRP levels?
Can medications affect CRP levels?
Yes, some medications can affect CRP levels. Anti-inflammatory drugs, such as corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs), can lower CRP levels. Before a CRP test, the doctor should be informed of all medications taken.
How long does it take for the CRP level to normalize after inflammation?
How long does it take for the CRP level to normalize after inflammation?
CRP levels usually decrease within a few days after the cause of the inflammation is treated. However, in chronic cases, CRP levels may remain elevated for longer periods and regular monitoring may be necessary.
