Estradiol (E2) is the most important estrogen in the body and plays a central role in fertility and the female cycle. It is predominantly produced in the ovaries, and in smaller amounts in the testes and adrenal glands in men. Estradiol also influences bone metabolism, the skin, and the cardiovascular system.
High estradiol levels are found, for example, during ovulation, pregnancy, or hormone therapies. Low levels occur during menopause and can be associated with symptoms such as hot flashes, sleep disturbances, or bone loss.
