Core messages
💡 Cortisol is the stress hormone and affects energy and health.
💡 An imbalance can promote fatigue, sleep problems, and burnout.
💡 Blood tests help identify stress levels and take targeted action.

Stress in everyday life
In our fast-paced world, the demands on body and mind are constantly increasing, and many people feel increasingly overwhelmed and stressed. Chronic stress is one of the main triggers for the so-called burnout syndrome – an exhaustion crisis that can have serious health consequences in many cases.
A central role in stress management is played by the hormone cortisol. But why is the cortisol level so important? In this article, we take a look at the function of cortisol, the importance of a healthy cortisol level, and the reference ranges used to assess this value. Additionally, we introduce other important values that contribute to stress and burnout diagnosis.
We also recommend the excellent article by AOK for more in-depth information: How Cortisol and Stress are Related as well as the article by Helios Health.

Cortisol – the stress hormone
Cortisol, often referred to as the "stress hormone" , is produced in the adrenal cortex and plays a central role in responding to stressful situations. During stress phases, cortisol levels rise to make the body alert and release energy reserves – an adaptation that was crucial for survival in human evolution to quickly respond to threats.
When stress becomes a constant burden
In a healthy body, cortisol levels normalize after a stress phase. However, with persistent stress or chronic overload , cortisol levels often remain permanently elevated.This can lead to a variety of health problems, including:
- Sleep disorders
- Weight gain
- Depression
- Weakened immune defense
Stress management for a healthy cortisol level
Targeted stress management and a balanced lifestyle can help regulate cortisol levels again. This includes getting enough sleep, regular exercise, relaxation techniques such as meditation or breathing exercises, and a healthy diet.

Cortisol and Burnout: A Dangerous Combination
Burn-out is far more than "just" stress – it is a profound physical and mental exhaustionthat is often closely associated with a disrupted cortisol level .
Initially, chronic stress often leads to permanently elevated cortisol levels, which is a clear sign of overload and significantly increases the risk of burn-out . However, in the advanced stage of burn-out, the cortisol level can drastically drop: The adrenal glands are overworked and no longer produce sufficient cortisol. This is an indication that the body has exhausted its adaptive capacity .
Cortisol levels and reference ranges
Measurement instructions
To correctly interpret the cortisol level , it is important to know the natural fluctuations throughout the day. Cortisol follows a circadian rhythmthat varies depending on the time of day.
In the morning , the cortisol level reaches its peak to activate the body for the day and enhance performance. Over the course of the day, the level should gradually decrease so that it is low in the evening , helping the body to relax and fall asleep.
Disruptions of this rhythm – such as consistently elevated levels or a high cortisol level in the evening – can indicate chronic stress, burnout , or other stress-related disorders . Accurate measurement helps to detect these deviations early and counteract them specifically.
Reference ranges depending on the time of day
The cortisol level varies throughout the day and follows a natural rhythm. The reference values for healthy adults are:
Morning (7–9 AM): 200–700 nmol/L
Afternoon: 100–400 nmol/L
Evening: < 100 nmol/L
Cortisol Imbalance: Recognize Symptoms
An imbalanced cortisol level – whether persistently elevated or too low – can affect the entire body. Since cortisol plays a key role in energy balance and stress management , imbalances often lead to symptoms that develop gradually and are easily overlooked or attributed to other health issues.
Symptoms of elevated cortisol levels:
- Chronic fatigue and exhaustion: Despite adequate sleep, affected individuals feel constantly tired and lacking energy.
- Weight gain, especially around the abdomen: Cortisol promotes fat storage, particularly in the abdominal region.
- Sleep disturbances: An elevated cortisol level makes it difficult to fall or stay asleep, especially in the early morning hours.
- Concentration and memory problems: High cortisol levels impair brain function and lead to concentration difficulties.
- Mood swings and irritability: A disrupted cortisol level affects the neurotransmitters, which can lead to mood swings and irritability.
- High blood pressure and heart palpitations: Cortisol increases heart rate and can raise blood pressure in the long term – a risk factor for cardiovascular diseases.
- Weakened Immune System: A persistently elevated cortisol level weakens the immune system and increases susceptibility to infections.
Important: If you notice one or more of these symptoms, a cortisol test can provide valuable insights. Early diagnosis and targeted measures can effectively manage the effects of a disrupted cortisol level.

Specific symptoms in women
An imbalanced cortisol level can cause additional or intensified symptoms in women, closely related to hormonal fluctuations and the menstrual cycle .
Typical symptoms in women:
- Irregular menstrual cycle or missed periods: A persistently high cortisol level affects the hormonal balance and can lead to menstrual disorders .
- Changes in skin health: Many women experience increased skin problems, such as acne or dry skin, with elevated cortisol.
- Increased hair loss: Hormonal imbalances and persistent stress can lead to hair loss or thinning hair.
- Stronger PMS Symptoms: Women often report increased premenstrual complaints such as headaches, mood swings, and water retention.
- Loss of Libido: A disrupted cortisol level can affect sex hormones, such as testosterone, and decrease sexual interest .
- Increased Risk of Osteoporosis: Long-term high cortisol levels can reduce bone density and thus increase the risk of osteoporosis, especially in women.
Cortisol and the Female Body
These symptoms illustrate how significantly the hormone Cortisol can influence not only the general state of health but also the female hormonal balance and well-being . Early monitoring of cortisol levels provides women with the opportunity to take targeted countermeasures and support their health sustainably.

Additional relevant values for burnout diagnosis
In addition to cortisol levels, there are other important blood values that provide information about the body's stress load and degree of exhaustion:
- Folic Acid: Folic acid is essential for cell regeneration and the production of neurotransmitters. A folic acid deficiency can contribute to exhaustion, cognitive impairments, and impaired stress management. Folic acid is also important for blood formation and the nervous system.
- Transcobalamin (Vitamin B12 transport protein): Transcobalamin binds vitamin B12 and transports it into the cells.A deficiency can lead to vitamin B12 deficits, which impair the nervous system and cognitive function, promoting symptoms such as fatigue, mood swings, and memory problems – symptoms often associated with burnout.
- DHEA (Dehydroepiandrosterone): DHEA is a hormone that is also produced in the adrenal glands. A healthy DHEA level is important because an imbalance between DHEA and cortisol can indicate chronic stress.
- CRP (C-reactive protein): A marker for inflammation in the body. Chronic stress can lead to an increased tendency for inflammation, which can be measured by the CRP level.
- Vitamin D: Vitamin D is important for the immune system and overall energy production.A low vitamin D level can contribute to fatigue and susceptibility to illnesses. Blood sugar: Stress can increase blood sugar as cortisol boosts the body's glucose output. Prolonged elevated blood sugar can indicate chronic stress. Thyroid levels (TSH, T3, T4): Since the thyroid also responds to stress, altered thyroid levels can be a sign of body exhaustion. By combining these values, the health status can be better assessed, and the relationship between stress and physical condition can be determined more precisely.
Next steps for your health
With
- Order the test kit and have it delivered to your home.
- Collect the sample independently – quickly and easily.
- Receive results: Your values are reliably analyzed and made available online.
A cortisol test from
Summary: Keeping an eye on your health
A balanced cortisol level is crucial for your well-being and stress management.A permanently elevated or disrupted cortisol level can indicate chronic stress and increase the risk of burnout .
In addition to cortisol, other values such as DHEA, CRP , and Vitamin D are valuable indicators for assessing stress levels.
With
FAQ: Frequently Asked Questions about Stress, Burnout, and Cortisol Levels
What is cortisol and what function does it have in the body?
What is cortisol and what function does it have in the body?
Cortisol is a hormone produced in the adrenal cortex and released during stress. It helps the body respond to stressful situations by releasing energy and increasing blood sugar. However, cortisol also has many other functions, including regulating blood pressure and supporting the immune system.
What symptoms occur with an unbalanced cortisol level?
What symptoms occur with an unbalanced cortisol level?
An unbalanced cortisol level can lead to fatigue, sleep disorders, weight gain, concentration problems, and high blood pressure. Women may also suffer from menstrual disorders, hair loss, and more severe PMS symptoms.
How is the cortisol level measured?
How is the cortisol level measured?
The cortisol level can be measured through a blood, saliva, or urine sample. Measuring at specific times of the day provides particularly meaningful results, as the cortisol level naturally fluctuates throughout the day.
What reference values apply to cortisol levels?
What reference values apply to cortisol levels?
The reference values for cortisol vary depending on the time of day. In the morning, cortisol levels should be between 200 and 700 nmol/L, in the afternoon around 100–400 nmol/L, and in the evening below 100 nmol/L. Deviations may indicate chronic stress or other health issues.
What causes a persistently elevated cortisol level?
What causes a persistently elevated cortisol level?
A persistently elevated cortisol level can be caused by chronic stress, lack of sleep, overweight, an unhealthy diet, and certain conditions such as Cushing's syndrome. In the long term, a high cortisol level can promote health problems.
How can you lower cortisol levels?
How can you lower cortisol levels?
The cortisol level can be lowered through regular exercise, sufficient sleep, relaxation techniques such as meditation, and a healthy diet. Avoiding caffeine and nicotine, as well as maintaining social contacts, can also help regulate cortisol levels.
What are the effects of low cortisol levels?
What are the effects of low cortisol levels?
A low cortisol level can lead to fatigue, low blood pressure, dizziness, and a weakened immune system. These symptoms often occur with adrenal insufficiency, which can result from chronic stress or prolonged overproduction of cortisol.
Why are cortisol levels particularly important in women?
Why are cortisol levels particularly important in women?
In women, an imbalanced cortisol level can additionally influence hormonal fluctuations, which can lead to cycle disorders, intensified PMS symptoms, and skin problems. In the long term, a high cortisol level increases the risk of osteoporosis, which is particularly significant for women.
Can you test cortisol levels yourself?
Can you test cortisol levels yourself?
Yes, cortisol levels can be measured with a simple home test. In this process, a sample, such as a saliva or blood sample, is taken and analyzed in the laboratory. This way, you can conveniently check your cortisol levels from home.
Why is the cortisol level higher in the morning than in the evening?
Why is the cortisol level higher in the morning than in the evening?
The cortisol level is higher in the morning as it prepares the body for the day and provides energy. Throughout the day, the level decreases to be low in the evening, preparing the body for recovery and sleep.